Business Verified eBay Store Seal Watch Video Watch Video

A microRNA-mediated mechanism that is epigenetically inherited

Posted on August 8, 2014 by James Kohl.

Pregnancy Stress Spans Generations

The stressors a female rat experiences during pregnancy can have repercussions for her granddaughters, a study shows.

By Anna Azvolinsky | August 7, 2014

Excerpt: “These changes could be the result of a microRNA (miRNA)-mediated mechanism, which may be epigenetically inherited across generations.”

My comment: 

There is currently no alternative explanation for these changes. However, a model of how nutrient-dependent pheromone-controlled amino acid substitutions link cell type differentiation (e.g., from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man via conserved molecular mechanisms) explains how nutrient-dependent changes in the microRNA/messenger RNA balance cause effects on hormone-organized behaviors that also are affected by hormones.

Yes, it’s complicated! However, the link from ‘effect’ to ‘affect’ was explained in Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. Bruce McEwen also focussed on the difference between  ‘effect’ and ‘affect’ in a correction to Brain on stress: How the social environment gets under the skin

Simply put, evolutionary theorists must realize that ecological variation and nutrient uptake are required for changes to the microRNA/messenger RNA balance. Those changes result in cell type differentiation via amino acid substitutions, which stabilize DNA in organized genomes. Until evolutionary theorists begin to think in terms of biophysically-constrained protein folding, they may continue to tout the pseudoscientific nonsense of mutation-initiated natural selection and the evolution of biodiversity.

Fortunately, serious scientists know that mutations perturb protein-folding, which means that mutations do not stabilize DNA in organized genomes. That’s why mutations cannot be linked from ecological variation to epigenetic effects on hormones that affect behavior manifested in increasing organismal complexity associated with morphological phenotypes.

Clearly, the evolutionary theorists can explain differences in morphological phenotypes that arise from mutations. But the fact that they cannot explain how mutations could effect hormones, which affect behavior, leaves some serious scientists wondering.

In the early 1990s, I began to wonder why the theorists were unable to think in terms of olfactory/pheromonal input, which we now know epigenetically effects hormones that obviously link ecological variation to ecological adaptations via affects on behavior. Recently, it has become clearer that evolutionary theorists cannot think about anything outside the context of mutation-initiated natural selection and the evolution of biodiversity.  Some of them are even attempting to re-invent their theories using the term “epimutation.”

I hope that serious scientists will stop that pseudoscientific nonsense before it becomes accepted as if it were based on any experimental evidence of biologically-based cause and effect whatsoever.  See for comparison: Nutrient-dependent/pheromone-controlled adaptive evolution: a model The model includes examples from different species that attest to facts about how amino acid substitutions link a microRNA-mediated mechanism that is epigenetically inherited from ecological variation to nutrient-dependent pheromone-controlled ecological adaptations, without any nonsense about mutation-driven evolution.

For contrast: Nei (2013) wrote: “…genomic conservation and constraint-breaking mutation is the ultimate source of all biological innovations and the enormous amount of biodiversity in this world.”

That’s nonsense! Ecological variation in the supply of nutrients leads to the nutrient-dependent pheromone-controlled physiology of reproduction and nutrient-dependent ecological adaptations manifested in the inherited morphological and behavioral phenotypes of species from microbes to man.



James Kohl
Retired medical laboratory scientist

James Kohl

Order by Mail or FAX

Order by Mail or Fax

If you prefer to place your pheromones order by MAIL or FAX, using our printable order form, click here.

Trademarks & Notices: LuvEssentials is not affiliated in any way with WebMD, CNN, Discovery Health. All trademarks and registered trademarks appearing on LuvEssentials are the property of their respective owners.

Orders that were shipped by free USPS Mail and are returned to us will be assessed a return processing fee of $7.00 US Dollars. Orders totaling over $190.00 US Dollars, before any discount, that are returned to us will be assessed a return processing fee of 25%.

Please note, the testimonials we display are all real; however, any photos accompanying these testimonials are stock photography, not actual customers. We do this to protect the privacy of our customers.

Also, in accordance with FTC guidelines, we want to make it explicitly clear that the testimonials we display throughout this website are based on the unique experiences that some of our customers have shared with us. We cannot promise that you will experience similar benefits from using our product. If you are not satisfied with our product for any reason, simply return the product within 60 days for a full refund excluding the costs of shipping and handling. Please contact us with any questions you may have.

James Kohl owns, and he has published books and award-winning research journal articles about human pheromones. With colleagues he was the first to show that a mixture of human pheromones increases the flirtatious behaviors of women, and increases their level of attraction to the man wearing the mixture - during a real-life social circumstance lasting 15 minutes.

James Kohl was not paid for his endorsement. Nevertheless, he is an affiliate of which means it is possible for him to receive a monetary gain from the sale of LuvEssentials products based on how the visitor arrived at our site.

For testimonials of LuvEssentials products, please visit our testimonials page here or our ebay reviews page here.

To contact us, please click here

Contact Us

Please complete the following form to contact us; we will reply within one business day.
Business days are Monday through Friday, 9:00 AM to 5:00 PM, EST
The information you are providing here will not be sold or disclosed to any outside party.
(* indicates required fields)

Please contact us by:



Lodix Corporation
138 Palm Coast Parkway N.E.
Suite 192
Palm Coast, FL 32137

What is the vomeronasal organ (VNO)?

The vomeronasal organ (VNO) is a cone-shaped organ in the nasal cavity, which is believed to be one of the body's receptors of pheromones. More, specifically, the VNO, which is part of the accessory olfactory system in the nose, does not respond to normal scents, but may detect odorless, barely perceptible pheromones.

Other schools of thought believe that it is not the VNO but rather cells in our main olfactory system and their affects on hormones secreted by the hypothalamus that are responsible for the affects of pheromones.

Learn more about the science behind pheromones here.

What are optimized pheromones?

Optimized pheromones are lab-certified pheromone formulations that have the optimum concentration of biologically active pheromones scientifically proven to produce behavior-altering results -- particularly as sexual attractants. Optimized pheromone formulations do not necessarily contain the maximum level of pheromones available on the market, but rather contain the greatest degree (and combination)of human pheromones that trigger a conditioned biological response in humans that, in turn, dictate their sexual behavior. Optimized pheromones also release neurotransmitters that directly modify the behavior of the opposite sex, such as triggering sexual excitement. For example:

Optimized pheromones for men are scientifically proven to bring about an increase in the luteinizing hormone (LH) in women, thereby causing a woman to have a heightened sexual responsiveness to a man. This LH surge elevates a woman's predisposition towards sexual activity.

Optimized pheromones for women are scientifically proven to bring about a biochemical surge in men, thereby causing a man to have a heightened sexual responsiveness to a woman. This biochemical surge is what makes a man fiercely determined to copulate.