Posted on January 7, 2010 by jim.
Miller and Maner (2009) helps to establish the link from human pheromones to behavior. It shows that human pheromones elicit changes in hormone levels. There’s a well detailed pathway to changes in testosterone (T) that starts with gene activation in hormone-secreting cells of hypothalamic tissue in the brain, which is the organ that controls our behavior. What this means is that human pheromones are chemicals found in our social environment that directly activate a gene-cell-tissue-organ-organ system pathway, which directly links pheromones to behavior.
Scent of a Woman (from Psychological Science) by Saul L. Miller and Jon K. Maner “The current research provides evidence that ovulatory cues are detectable via chemosensory signaling and, moreover, that these cues are linked with functionally relevant endocrinological responses in men.”
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Posted on January 7, 2010 by jim.
Berliner, David L; Jennings‑White, Clive L., Adams, Nathan W. (1996) Pregnane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods. United States Patent # 5,563,13
The above patent incorporates the false concept that human pheromones act via the human vomeronasal organ (VNO), which has been shown to be non-functional. Nevertheless, this research and marketing group (see below) might have been the first to show effects of a progesteronic (luteal phase) pheromone on testosterone levels in men.
Berliner, D.L., Monti‑Bloch, L., Jennings‑White, C., & Diaz‑Sanchez, V. (1996) Functionality of the human vomeronasal organ (VNO): Evidence for steroid receptors. Journal of Steroid Biochemistry and Molecular Biology, 58, 3, 259‑265.…
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Posted on December 4, 2009 by James Kohl.
12-04-2009 12:05 AM
Abstract: Pheromones have been shown to induce sexually dimorphic responses in LH secretion. Here we asked whether the sexually dimorphic population of kisspeptin neurons in the rostral periventricular area of the third ventricle(RP3V) could relay sexually dimorphic information from the olfactory systems tothe GnRH system. Furthermore, we analyzed the effects of aromatase mutation(ArKO) and thus the role of estradiol on RP3V kisspeptin neuronal numbers and on the response of these kisspeptin neurons to same- versus opposite-sex urinary pheromones. Exposure to male but not female urinary odors induced Fos protein in kisspeptin neurons in the RP3V of female wildtype (WT) mice, suggesting that these kisspeptin neurons may be part of the neural circuitry that relays information from the olfactory brain to the GnRH system in a sexually dimorphic manner. Male pheromones induced Fos in kisspeptin neurons in ArKO females,albeit significantly less compared to WT females. The sexual differentiation of kisspeptin neuronal number was lost in ArKO mice, i.e. the number of kisspeptin-immunoreactive neurons in the RP3V of ArKO females was as low as in male mice, whereas male ArKO mice had somewhat increased numbers of kisspeptin neurons. These results suggest that the sex difference in kisspeptin neuronal number in WT mice reflects an organizational action of estradiol in females. By contrast, the ability of male urinary pheromones to activate kisspeptin neurons in WT females may not depend on the organizational action of estradiol since ArKO females still showed some Fos/kisspeptin co-activation.
Effects of aromatase mutation (ArKO) on the sexual differentiation of kisspeptin neuronal numbers and their activation by same versus opposite sex urinary pheromones InPress, Uncorrected Proof Available online 27 November 2009
Julie Bakker, Sylvie Pierman, David González-Martínez ——————————————————————————————- The first line of the abstract (above) is: “Pheromones have been shown to induce sexually dimorphic responses in LH secretion.” my emphasis added. This article, when published, will help to further establish the credibility of the model I’ve been presenting since the early 1990’s.
The title of my first presentation to a scientific congress was Luteinizing hormone: (LH) the link between sex and the sense of smell? The question mark in my title was suggested by a reviewer because — at that time — no one could be sure that LH was the link. It is!
Julie Bakker’s group has helped to detail a sexually dimorphic pathway from pheromones to hormones (and thus to behavior) in mammals, which we …
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