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How biodiversity arises

Posted on July 21, 2014 by James Kohl.

Effects of starvation can be passed to future generations, through small RNAs apparently without DNA involvement

Excerpt: The findings have no immediate clinical application. “However, they do suggest that we should be aware of other things — beyond pure DNA changes — that may have a long-term impact on the health of an organism,” said Dr. Hobert. “In other words, something that happened to one generation, whether famine or some other traumatic event, may be relevant to the health of its descendants for generations.”

My comment: The findings refute all aspects of mutation-initiated natural selection in the context of evolved biodiversity. They replace the pseudoscientific nonsense of population geneticists with facts on how starvation epigentically effects cell type differentiation.

Starvation prompts seemingly futile cycles of thermodynamically regulated protein biosynthesis and degradation. Ecological variation links any nutrient with the potential to cause a base pair change that results in an amino acid substitution to ecological adapations via stablization of the organized genome in organisms that are starving to death.  Starvation-induced changes in the microRNA/messenger RNA balance link ecological variation and nutrient-uptake to the pheromone-controlled physiology of reproduction in species from microbes to man. Changes in the balance lead to amino acid substitutions that differentiate the cell types of species via conserved molecular mechanisms, which is how biodiversity arises.

The claim that “The findings have no immediate clinical application” must be examined in the context another report:

Marmoset sequence sheds new light on primate biology and evolution

Excerpt: “…found marmosets exhibit a significant number of differences in microRNAs and their gene targets compared with humans, with two large clusters potentially involved in reproduction.”

My comment: In my model, differences in the microRNA/messenger RNA balance cause amino acid substitutions that differentiate cell types. Dobzhansky (1973) mentioned the amino acid substitutions in this context: Nothing in Biology Makes Any Sense Except in the Light of Evolution (link opens pdf). “…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.”

Unfortunately, researchers who think that the transgenerational epigenetic effects of starvation have no clinical significance may not attempt to determine which nutrient-dependent pheromone-controlled amino acid substitutions differentiate the cell types of C. elegans from P. pacificus or which amino acid substitutions differentiate the cell types of marmosets from those of other primates.

found…
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Biology Developments

Posted on July 9, 2014 by James Kohl.

No one has commented on my posts to the “Biology Developments” Facebook page despite the clear indications that theories proposed by population geneticists are rapidly falling out of favor as the theories are replaced with facts about biologically based cause and effect.

Personally, I think my posts tend to scare some researchers who had hoped they could continue to tout their belief in the theory they were taught to believe in, as if experimental evidence in the context of biology developments had ever supported it.

I’m linking to some of the information in the posts just to show how quiet the group is. Like other groups, there seems to be no participants willing to discuss new research results, like these:

Conserved microRNA editing in mammalian evolution, development and disease

Excerpt: “…site-specific miRNA editing is an evolutionarily conserved mechanism, which increases the functional diversity of mammalian miRNA transcriptomes.”

Excerpt 2): “…miRNA editing is an integral and evolutionarily stable feature of mammalian transcriptomes.”

My comment: It’s time for social scientists and serious scientists alike to admit that site-specific miRNA editing is nutrient-dependent and pheromone-controlled. Biological facts continue to refute the pseudoscientific nonsense of mutation-initiated natural selection and evolved biodiversity.

From Kohl (2013) “In flies, ecological and social niche construction can be linked to molecular-level cause and effect at the cellular and organismal levels via nutrient-dependent changes in mitochondrial tRNA and a nuclear-encoded tRNA synthetase. The enzyme enables attachment of an appropriate amino acid…”

Diet in mammals is complex

Journal article excerpt: “…continuing to work instead with untested dietary classifications would generate unstandardized results and thereby prevent synergy between intellectually overlapping ecological and palaeoecological research programmes.”

My comment: “Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems” is the requested but rejected review of nutritional epigenetics that refutes neo-Darwinian theories and links the pheromone-controlled physiology of reproduction to the synergy that is required to integrate intellectually overlapping ecological and palaeoecological research programmes. Those who examine only nutrition or only reproduction may never realize that ecological variation and nutrient-dependent amino acid substitutions enable the pheromone-controlled physiology of species-specific reproduction, which is manifested in the morphological and behavioral phenotypes of species from microbes to man. Many social scientists, for example, still think in terms of mutation-initiated natural selection instead of natural selection for nutrients. That explains why social scientists believe in biologically implausible theories that were invented by population geneticists. They …


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Conserved microRNA editing

Posted on July 8, 2014 by James Kohl.

Conserved microRNA editing in mammalian evolution, development and disease

Excerpt:  “…site-specific miRNA editing is an evolutionarily conserved mechanism, which increases the functional diversity of mammalian miRNA transcriptomes.”

Excerpt 2): “…miRNA editing is an integral and evolutionarily stable feature of mammalian transcriptomes.”

My comment: It’s time for social scientists and serious scientists alike to admit that site-specific miRNA editing is nutrient-dependent and pheromone-controlled. Biological facts continue to refute the pseudoscientific nonsense of mutation-initiated natural selection and evolved biodiversity.

See also: Healthy people carry disease-causing mitochondrial DNA mutations.

Excerpt: “… pathogenic mtDNA mutations are usually present at low frequency and buffered by healthy mtDNA, preventing the action of natural selection.

My comment: Few people are willing to publicly admit that ecological variation results in ecological adaptations via conserved molecular mechanisms in species from microbes to man. However, removing the theory of mutation-initiated natural selection from any further consideration will help move science forward in the context of cell type differentiation via amino acid substitutions.

For example (from Kohl, 2013) : “In flies, ecological and social niche construction can be linked to molecular-level cause and effect at the cellular and organismal levels via nutrient-dependent changes in mitochondrial tRNA and a nuclear-encoded tRNA synthetase. The enzyme enables attachment of an appropriate amino acid, which facilitates the reaction required for efficient and accurate protein synthesis (Meiklejohn et al., 2013).”

Ecological variation is manifested in ecological adaptations via amino acid substitutions that differentiate cell types in all individuals of all species. Thus, the only stable feature of mammalian transcriptomes arises in the context of nutrient-dependent pheromone-controlled ecological adaptations, and not in the context of mutation-initiated natural selection.…


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Ecological adaptation: The third way

Posted on July 3, 2014 by James Kohl.

The Third Way

The vast majority of people believe that there are only two alternative ways to explain the origins of biological diversity. One way is Creationism that depends upon supernatural intervention by a divine Creator. The other way is Neo-Darwinism, which has elevated Natural Selection into a unique creative force that solves all the difficult evolutionary problems. Both views are inconsistent with significant bodies of empirical evidence and have evolved into hard-line ideologies. There is a need for a more open “third way” of discussing evolutionary change based on empirical observations.

Contact:

Excerpt: “Please do get in touch if you would like to recommend a scientist or their work to add to the list. We would also like to hear if you have any relevant books or news items that you would like us to include on the website.”

My request for consideration:

A series of published works on cell type differentiation began with From Fertilization to Adult Sexual Behavior in 1996.

Excerpt: “Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.” (p. 337)

Sex differences in cell types that are responsible for sex differences in morphology and behavior arise in the context of ecological variation and the conserved molecular mechanisms that have since been detailed in my other published works on adaptive evolution.

Kohl, J.V. (2013) Nutrient-dependent/pheromone-controlled adaptive evolution: a model. Socioaffective Neuroscience & Psychology, 3: 20553.

Kohl, J.V. (2012) Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. Socioaffective Neuroscience & Psychology, 2: 17338.

I would like these works to be considered for inclusion at The Third Way of Evolution.com

Thank you for your consideration in this regard,

James V. Kohl Medical laboratory scientist (ASCP) Independent researcher…
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Biological evolution: a direct contradiction

Posted on June 28, 2014 by James Kohl.

Biological evolution: Some genetic considerations

It will probably not be long until at least one prominent evolutionary theorist acknowledges this fact, “The concept of biological evolution… stands in direct contradiction with our current knowledge regarding the behavior as well as the structural and functional characteristics of the human genome and human proteome.”

When that fact is acknowledged, all of evolutionary theory will be exposed for what it has been since the invention of neo-Darwinism, which placed mutations and natural selection before ‘conditions of life’ that are obviously nutrient-dependent and pheromone-controlled.

Others may then ask evolutionary theorists why they thought mutations were the source of biodiversity, which is obviously nutrient-dependent and what they thought controlled the physiology of reproduction in species from microbes to man. The metabolism of nutrients to species-specific pheromones controls the physiology of reproduction. Ask a theorist how they could not know that fact.…


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