Disorders of development: altered microRNA / messenger RNA balance
Posted on November 23, 2012 by James Kohl.
My recent poster presentation helps to explain the microRNA / messenger RNA balance in the context of adaptively evolved cell and organism homeostasis. For example, dietary or social stress can result in altered homeostasis, which results in physical and mental disorders. The biological complexity of the model is overwhelming but this 2-minute video representation on the importance of microRNA to physical disorders may prompt neuroscientists to examine my model and my published works in an attempt to learn more about how the altered microRNA / messenger RNA balance results in disorders of brain development and behavior.
From my poster: Main conclusion:
This model of systems biology (“biological embedding”) represents:
Nutrient chemical-dependent and social stress-induced intracellular changes in microRNA and messenger RNA homeostasis
Intermolecular changes in DNA
Experience-dependent stochastic variations in de novo gene expression for odor receptors
The required gene-cell-tissue-organ-organ system pathway that links sensory input directly to gene activation in GnRH neurosecretory cells of the mammalian brain
The required reciprocity that links gene expression to behavior that alters gene expression (i.e. from genes to behavior and back)
A model of how mutations might somehow cause adaptive evolution can now be compared to this model of nutrient chemical-dependent non-random adaptive evolution that is controlled by the epigenetic effects of pheromones on reproduction in species from microbes to man.
Retired medical laboratory scientist
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