Epigenetic effects of diet, chemicals, and other severe stresses
Posted on April 6, 2013 by James Kohl.
Trait vs. Fate” in the May 2013 issue of Discover magazine [subscription required]
Excerpt (with my emphasis): “If diet and chemicals can cause epigenetic changes [epigenetic effects], could certain experiences — child neglect, drug abuse or other severe stresses also set off epigenetic changes to the DNA inside the neurons of a person’s brain?”
My comment (February 2013): Nutrient-dependent / Pheromone-controlled Adaptive Evolution [open access]
This model of systems biology [and epigenetic effects] represents the conservation of bottom-up organization and top-down activation via:
Nutrient stress-induced and social stress-induced intracellular changes in the microRNA (miRNA) / messenger RNA (mRNA) balance;
Intermolecular changes in DNA (genes) and alternative splicing;
Non-random experience-dependent stochastic variations in de novo gene expression and biosynthesis of odor receptors;
The required gene-cell-tissue-organ-organ system pathway that links sensory input directly to gene activation in neurosecretory cells and to miRNA-facilitated learning and memory in the amygdala of the adaptively evolved mammalian brain;
The required reciprocity that links gene expression to behavior that alters gene expression (i.e., reciprocity from genes to behavior and back) in model organisms like the honeybee.
Retired medical laboratory scientist
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