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Human pheromones and diet-mediated life-extension

Posted on August 15, 2012 by James Kohl.

Study pinpoints genes involved in diet-mediated life-extension

August 14, 2012 By Julie Owens in Genetics

Excerpt: “Some of the new genes identified may have similar functions in humans and….were initially discovered in yeast, so we definitely want to continue this work with a view of ultimately tackling the human ageing process and developing treatments for age-related diseases.”

My comment:

The essential genes tend to be located in the center of the interactome rather than in the periphery, which suggests the central role for regulation of cell division by nutrient chemicals, like glucose. Glucose also regulates gonadotropin releasing hormone (GnRH) from what might be called the center of the mammalian interactome: the hypothalamic GnRH pulse.

In mammals, the epigenetic effects of nutrient chemicals and pheromones link GnRH pulse frequency  to nutrient chemical-dependent species-specific behaviors via adaptive evolution through ecological, social, neurogenic, and socio-cognitive niche construction. However, there is no denying the role of dietary fatty acids in GnRH-directed socio-cognitive niche construction, so continue taking your fish oil supplements.

The article makes that clear and also makes clear the likelihood that yeast cells managed to evolve into intelligent mammals, which means there is still hope that your co-workers might do so through the epigenetic effects of nutrient chemicals and pheromones. Did I ever mention that the yeast mating pheromone is so similar to mammalian GnRH — a molecule conserved across 400 million years of vertebrate evolution — that it elicits a luteinizing hormone (LH) response from the cultured pituitary cells of a mammal: the rat? The LH response, for example, is a central focus of my model.

Kohl, J.V. (2012) Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. Socioaffective Neuroscience & Psychology, 2: 17338.

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James Kohl
Retired medical laboratory scientist

James Kohl




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