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Human Pheromones: Diversity of signaling pathways and a common response

Posted on July 29, 2012 by James Kohl.

Smell the potassium: Surprising find in study of sex- and aggression-triggering vomeronasal organ.”

Article excerpt: “The diversity of signaling pathways perhaps make it more robust in triggering innate behaviors.” –C. Ron Yu, Ph.D., senior author of the study.

My comment:

Whether the required receptor-mediated signal transduction occurs via a VNO and AOS or through the main olfactory system (MOS), it is the molecular biology common to all species that assures us olfaction and odor receptors provide a clear evolutionary trail, which can be followed from unicellular organisms to insects to humans.

The GnRH-directed luteinizing hormone (LH) response, which links the epigenetic effects of human pheromones and food odors directly to the socioaffective nature of evolved behaviors exemplifies adaptive evolution of a common response to food odors and mammalian pheromones, including human pheromones, as detailed in: Kohl, J.V. (2012) Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. Socioaffective Neuroscience & Psychology, 2: 17338.

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James Kohl
Retired medical laboratory scientist

James Kohl




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What is the vomeronasal organ (VNO)?

The vomeronasal organ (VNO) is a cone-shaped organ in the nasal cavity, which is believed to be one of the body's receptors of pheromones. More, specifically, the VNO, which is part of the accessory olfactory system in the nose, does not respond to normal scents, but may detect odorless, barely perceptible pheromones.

Other schools of thought believe that it is not the VNO but rather cells in our main olfactory system and their affects on hormones secreted by the hypothalamus that are responsible for the affects of pheromones.

Learn more about the science behind pheromones here.

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