MicroRNA / messenger RNA balance-controlled adaptive evolution

August 19, 2013 | James Kohl

Relative germ cell vulnerability throughout the lifespan may depend on the type of perturbation encountered, with severe caloric restriction and chronic stress eliciting distinct mechanisms.Excerpted from: Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation.

“This model of systems biology represents the conservation of bottom-up organization and top-down activation via the 1) thermodynamics of nutrient stress-induced and social stress-induced intracellular changes in the microRNA / messenger RNA (miRNA/mRNA) balance…” Excerpted from: Nutrient-dependent / pheromone-controlled adaptive evolution:

In mammals, the distinct mechanisms that enable transgenerational effects of caloric restriction (i.e., nutrient stress) and chronic stress (e.g., social stress) incorporate the same neuronal systems that result in subtle changes in gonadotropin releasing hormone (GnRH) pulse frequency. The subtle changes in GnRH  pulse frequency allow transmission of information from the external and internal environment in a manner that Sir Paul Nurse has compared to Morse Code, which enables transmission of the works of Shakespeare across widely distributed networks.

When compared to mutation-driven evolution, my model of Nutrient-dependent / pheromone-controlled adaptive evolution eliminates theory and replaces it with evidence of cause and effect, which includes evidence of conserved molecular mechanisms across species from microbes to man. It is the conservation of the molecular mechanisms that clearly shows adaptive evolution is nutrient-dependent and pheromone-controlled in all species. The epigenetic landscape becomes the physical landscape of DNA via finely tuned molecular mechanisms, not via random mutations.

My accurate representation of cause and effect is troublesome to theorists, which is why I am considered to be a problem among participants of the human ethology yahoo group.  For example, the common misrepresentation of visual primacy in birds, which was based on mutations theory, has been eliminated by accurate information on pheromones in birds that enable them to sniff out the best mate.  This fact makes some human ethologists look foolish and will expose them to ridicule as it becomes well known. However, it will become known, no matter how hard some ethologists try to suppress the dissemination of accurate information about biologically based cause and effect.

See for example, the misrepresentation of adaptive evolution in finches in How Evolution Works.  See also, the correct representation in: Forget Plumage, Birds Sniff Out Good Mates

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James Vaughn Kohl

James Vaughn Kohl

James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones.