Business Verified eBay Store Seal Watch Video Watch Video

Pheromones & epigenetically-effected circuit-based brain development

Posted on May 5, 2013 by James Kohl.

Re: NIMH Research Domain Criteria (RDoC),  pheromones, and epigenetically-effected circuit-based dimensions during the adaptively evolved development of the human brain and behavior

(RDoC) 1.  Environmental aspects. “The central nervous system is exquisitely sensitive to interactions with various elements of its environment virtually from the moment of conception.”

See for example: From Fertilization to Adult Sexual Behavior (vertebrates; a mammalian model).

(RDoC)  2. Environmental aspects. “The social and physical environment comprises sources of both risk and protection for many different disorders occurring at all points along the life span, and methods for studying such phenomena as gene expression, neural plasticity, and various types of learning are rapidly advancing.”

See for example: Organizational and activational effects of hormones on insect behavior (invertebrates; the honeybee model organism) Conclusion: While the insect literature contains numerous examples of hormone activation, explicit use of the organization concept provides a window into the developmental origins of phenotypic variation in behavior. It also broadens the time course over which hormonal actions on insect behavior are considered, from egg to adult.’

(RDoC)  3. Environmental aspects. “As with developmental aspects, environmental influences may thus be considered as another critical dimension of the RDoC matrix. The effects of a particular interaction with the environment, e.g., the effects of early child abuse, may pose risk for a wide variety of disorders. As another example, illicit drug use may cause sensitization of mesolimbic dopamine circuits that generalizes to other drugs of abuse and addictive behaviors. Thus, it is hoped that a research program organized around the relevant circuit-based dimensions that are affected, independent of a particular disorder, will accelerate knowledge regarding such environmental influences along the entire range of analysis from genes to behavior.”

See for example: Human pheromones: integrating neuroendocrinology and ethology

My comments on this section (paragraphs 1-3) of RDoC: In mammals, circuit-based dimensions that are epigenetically effected by sensory input from the social environment in species from microbes to man include the nutrient-dependent pheromone-controlled epigenetic effects on hypothalamic gondadotropin releasing hormone (GnRH). The epigenetic effects of olfactory/pheromonal input link a direct effect from nutrient stress and social stress to gene activation in hormone-secreting nerve cells of tissue in an organ (i.e., the brain), which is adaptively evolved to control organ systems via the feedback loops of multisensory integration, which are responsible for behavior. The central role of vertebrate GnRH is conserved across 400 million years of adaptive evolution. Its receptor diversifies and enables ecological and social niche construction, which results in neurogenic niche construction and socio-cognitive niche construction as is required for the adaptive evolution of embodied cognition. My model eliminates the mind/body dichotomy.

See for example: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences and the comment on my model by Simon Le Vay in Gay, Straight, and the Reason Why: The Science of Sexual Orientation. p. 210 ‘This model is attractive in that it solves the “binding problem” of sexual attraction. By that I mean the problem of why all the different features of men or women (visual appearance and feel of face, body, and genitals; voice quality, smell; personality and behavior, etc.) attract people as a more or less coherent package representing one sex, rather than as an arbitrary collage of male and female characteristics. If all these characteristics come to be attractive because they were experienced in association with a male- or female-specific pheromone, then they will naturally go together even in the absence of complex genetically coded instructions.”

And now, Simon’s caveat: “Still, even in fruit flies, other sensory input besides pheromones — acoustic, tactile, and visual stimuli — play a role in sexual attraction, and sex specific responses to these stimuli appear to be innate rather than learned by association [36.]. We simply don’t know where the boundary between prespecified attraction and learned association lie in our own species, nor do we have compelling evidence for the primacy of one sense over another.”

There is overwhelming evidence for the primacy of olfaction and pheromones in the nutrient-dependent pheromone-controlled development of behavior in species from microbes to man. Responses to olfactory/pheromonal input (e.g., nutrients that metabolize to pheromones) are innate. Species-specific responses to acoustic, tactile, and visual stimuli are learned via association with olfactory/pheromonal input.  Model organisms: yeast, nematodes, flies, ants, honeybees, mice, rats, sheep et al., exemplify nutrient-dependent pheromone-controlled development of behavior associated with single amino acid substitutions and genes of large effect. These genes are clearly responsible for species diversity that include nutrient-dependent sexually-selected phenotypic diversity in a human population that arose during the past ~30,000 years (Kohl, submitted).

See for example: Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. “”The concept that is extended is the epigenetic tweaking of immense gene networks in ‘superorganisms’ (Lockett, Kucharski, & Maleszka, 2012) that ‘solve problems through the exchange and the selective cancellation and modification of signals (Bear, 2004, p. 330)’. It is now clearer how an environmental drive probably evolved from that of food ingestion in unicellular organisms to that of socialization in insects. It is also clear that, in mammals, food odors and pheromones cause changes in hormones such as LH, which has developmental affects on sexual behavior in nutrient-dependent, reproductively fit individuals across species of vertebrates.”

What remains to be seen is whether my model will ever be incorporated into study designs based on the NIMH Research Domain Criteria (RDoC).

If it is not, I think we can expect progress to be slow in attempts to understand more about Nutrient-dependent / Pheromone-controlled Adaptive EvolutionNutrient-dependent / Pheromone-controlled thermodynamics and thermoregulation; Nutrient-dependent / Pheromone-controlled symbiosis; Nutrient-dependent / Pheromone-controlled morphogenesis; Nutrient-dependent / Pheromone-controlled epistasis; Nutrient-dependent / Pheromone-controlled embodied cognition; or mammalian nutrient-dependent pheromone-controlled Hypothalamic programming of systemic ageing involving IKK-b,NF-kB and GnRH.

 

Comments

comments

James Kohl
Retired medical laboratory scientist

James Kohl




Order by Mail or FAX

Order by Mail or Fax

If you prefer to place your pheromones order by MAIL or FAX, using our printable order form, click here.

Trademarks & Notices: LuvEssentials is not affiliated in any way with WebMD, CNN, Discovery Health. All trademarks and registered trademarks appearing on LuvEssentials are the property of their respective owners.

Orders that were shipped by free USPS Mail and are returned to us will be assessed a return processing fee of $7.00 US Dollars. Orders totaling over $190.00 US Dollars, before any discount, that are returned to us will be assessed a return processing fee of 25%.

Please note, the testimonials we display are all real; however, any photos accompanying these testimonials are stock photography, not actual customers. We do this to protect the privacy of our customers.

Also, in accordance with FTC guidelines, we want to make it explicitly clear that the testimonials we display throughout this website are based on the unique experiences that some of our customers have shared with us. We cannot promise that you will experience similar benefits from using our product. If you are not satisfied with our product for any reason, simply return the product within 60 days for a full refund excluding the costs of shipping and handling. Please contact us with any questions you may have.

James Kohl owns Pheromones.com, and he has published books and award-winning research journal articles about human pheromones. With colleagues he was the first to show that a mixture of human pheromones increases the flirtatious behaviors of women, and increases their level of attraction to the man wearing the mixture - during a real-life social circumstance lasting 15 minutes.

James Kohl was not paid for his endorsement. Nevertheless, he is an affiliate of LuvEssentials.com which means it is possible for him to receive a monetary gain from the sale of LuvEssentials products based on how the visitor arrived at our site.

For testimonials of LuvEssentials products, please visit our testimonials page here or our ebay reviews page here.

To contact us, please click here

Contact Us

Please complete the following form to contact us; we will reply within one business day.
Business days are Monday through Friday, 9:00 AM to 5:00 PM, EST
The information you are providing here will not be sold or disclosed to any outside party.
(* indicates required fields)

Please contact us by:

Phone:
800.611.3578

Email:
support@luvessentials.com

Mail:
Lodix Corporation
138 Palm Coast Parkway N.E.
Suite 192
Palm Coast, FL 32137


What is the vomeronasal organ (VNO)?

The vomeronasal organ (VNO) is a cone-shaped organ in the nasal cavity, which is believed to be one of the body's receptors of pheromones. More, specifically, the VNO, which is part of the accessory olfactory system in the nose, does not respond to normal scents, but may detect odorless, barely perceptible pheromones.

Other schools of thought believe that it is not the VNO but rather cells in our main olfactory system and their affects on hormones secreted by the hypothalamus that are responsible for the affects of pheromones.

Learn more about the science behind pheromones here.

What are optimized pheromones?

Optimized pheromones are lab-certified pheromone formulations that have the optimum concentration of biologically active pheromones scientifically proven to produce behavior-altering results -- particularly as sexual attractants. Optimized pheromone formulations do not necessarily contain the maximum level of pheromones available on the market, but rather contain the greatest degree (and combination)of human pheromones that trigger a conditioned biological response in humans that, in turn, dictate their sexual behavior. Optimized pheromones also release neurotransmitters that directly modify the behavior of the opposite sex, such as triggering sexual excitement. For example:

Optimized pheromones for men are scientifically proven to bring about an increase in the luteinizing hormone (LH) in women, thereby causing a woman to have a heightened sexual responsiveness to a man. This LH surge elevates a woman's predisposition towards sexual activity.

Optimized pheromones for women are scientifically proven to bring about a biochemical surge in men, thereby causing a man to have a heightened sexual responsiveness to a woman. This biochemical surge is what makes a man fiercely determined to copulate.