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Pheromones, GnRH, and brain development

Posted on April 19, 2013 by James Kohl.

Effects of peripubertal gonadotropin-releasing hormone agonist on brain development in sheep—A magnetic resonance imaging study exemplifies some of the latest research on molecular mechanisms of adaptive evolution. It also links the latest research to the central focus of my model of nutrient-dependent pheromone-controlled adaptive evolution. The link is via epigenetic effects of food odors and pheromones on gonadotropin-releasing hormone (GnRH).

GnRH is the biological core of mammalian reproductive sexual behavior. Nuruddin et al.,  may be the first in several years to put GnRH in its proper place, which is upstream from everything else involved in behavioral development. They write:

“GnRH is a decapeptide neurohormone that plays a key role in the reproductive axis, ultimately modulating therelease of gonadal steroid hormones. Its receptor (GnRHR) has been found in various brain regions, including the frontal cortex, the olfactory bulb and the limbic system (Albertson et al., 2008; Skinner et al., 2009; Chu et al., 2010; Rosati et al., 2011; Schang et al., 2011). Importantly, not all of these brain regions have roles in the control of reproductive function, suggesting that GnRH is involved in other processes and,as such, may modulate sex differences in emotional processing and cognitive functions.”

In the context above, you may think in terms of GnRH-dependent ecological, social, neurogenic, and socio-cognitive niche construction in mammals. When others realize it is GnRH that controls androgen secretion, like testosterone secretion, and controls oxytocin secretion as well as estrogen secretion, they may also begin to realize why attempts to link hormones to behavior without first linking sensory input to GnRH and other hormones is a ridiculous waste of time.

Those attempts lead to horrid misrepresentations of cause and effect in the context ofDarwinian natural selection. Selection is for nutrients that metabolize to pheromones that control reproduction. There’s a model for that, sans mutations theory! It’s the model I’ve been detailing since its first presentation in 1992.



James Kohl
Retired medical laboratory scientist

James Kohl

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James Kohl owns, and he has published books and award-winning research journal articles about human pheromones. With colleagues he was the first to show that a mixture of human pheromones increases the flirtatious behaviors of women, and increases their level of attraction to the man wearing the mixture - during a real-life social circumstance lasting 15 minutes.

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What is the vomeronasal organ (VNO)?

The vomeronasal organ (VNO) is a cone-shaped organ in the nasal cavity, which is believed to be one of the body's receptors of pheromones. More, specifically, the VNO, which is part of the accessory olfactory system in the nose, does not respond to normal scents, but may detect odorless, barely perceptible pheromones.

Other schools of thought believe that it is not the VNO but rather cells in our main olfactory system and their affects on hormones secreted by the hypothalamus that are responsible for the affects of pheromones.

Learn more about the science behind pheromones here.

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Optimized pheromones for men are scientifically proven to bring about an increase in the luteinizing hormone (LH) in women, thereby causing a woman to have a heightened sexual responsiveness to a man. This LH surge elevates a woman's predisposition towards sexual activity.

Optimized pheromones for women are scientifically proven to bring about a biochemical surge in men, thereby causing a man to have a heightened sexual responsiveness to a woman. This biochemical surge is what makes a man fiercely determined to copulate.