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Small RNAs and nutritional epigenetics (serious humor)

Posted on August 11, 2014 by James Kohl.

Serbian government honored me by putting me on their 20 recently

Honoring Amir’s sense of humor

 

In the context of nutritional epigenetics and “fitness,” small RNAs are clearly the drivers of ecological adaptations, which are globally manifested in affects on behavior associated with purchasing power.

Amir Siddiqui is an expert on fitness.

However, his size does not seem to matter in the context of biologically-based cause and effect linked from nutrition to epigenetic effects on hormones that affect behavior.

At the macroscopic level, appearances can be deceiving, even the appearance of faces on currency.

Amir Siddiqui is obviously big and healthy. But he may also know what others must remember. Nutrient-dependent microRNAs are the cause of everything, including our desire to eat more cheesecake (e.g., one of Amir’s favorites).

That fact was recently supported by experimental evidence reported as “The splicing modifiers reported here are orally bioavailable compounds that penetrate into all of the tissues we tested—including brain, spinal cord, and muscle—and consequently exert their action on SMN2 splicing in all cells of the body.” See:

SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy

Few others may understand what that means, but Amir exemplifies it. Across-species examples from model organisms are required. With examples they can see, others may better understand how the decisions we make about what to eat lead to nutrient-dependent changes in the microRNA/messenger RNA balance. Those changes lead from ecological variation to the amino acid substitutions that differentiate our cell types via the conserved molecular mechanisms that differentiate all the cell types of all individuals of all species from microbes to man.

Amir has a great sense of humor and his sense of humor is also an example of how people need not know anything about biophysical constraints and molecular mechanisms to understand what is obvious about nutritional epigenetics. We are what we eat!

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James Kohl
Retired medical laboratory scientist

James Kohl




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