Stress and controlled proliferation
November 19, 2013 | James Kohl
Scientists show that mice housed at room temperature are less able to fight tumors.
By Abby Olena | November 18, 2013
Excerpt: “It’s one of the things that’s under everybody’s nose, and nobody really thought about it much,” said Mark Dewhirst, a professor of radiation oncology and pathology at Duke University in North Carolina, who was not involved in the work. “Everybody thought that mice would be fine at room temperature, but nobody ever thought to look,” he continued. That the authors demonstrate “quite profound effects on antitumor immunity is really pretty remarkable,” Dewhirst added. “This is quite a tour de force.”
My comment: Here’s an outdated paradigm that is literally under everybody’s noses: Antibiotic resistance (a function of the innate immune system) is typically selected by the presence of the antibiotic.
No paradigm shift has occurred despite what is known about the link from physics to chemistry via thermal stress associated with nutrient stress during adaptations to the epigenetic “landscape” in species from microbes to man. How do organisms adapt?
Alternative splicings link the epigenetic landscape to the physical landscape of DNA in organized genomes. The alternative splicings clearly show that the adaptations are nutrient-dependent and pheromone-controlled. However, the nutrient-dependent pheromone-controlled adaptations are typically attributed to thermal stress and mutations. For example, this mistaken attribution occurs even in the context of exhibited resistance to rifampicin in E. coli that is clearly nutrient-dependent since a fitness advantage results within the context of a thermal stress/low glucose environment.
The molecular mechanisms of alternative splicings do not change across species. Nutrient stress is thermal stress and social stress is thermal stress, which is how why both nutrient stress and social stress can be linked to cancer and its progression. We should probably link nutrient stress and social stress to cancer treatment before running off half-cocked again as if we didn’t know about differences in temperature-controlled growth characteristics of other organisms (i.e., all of them) that link stress to their nutrient-dependent morphology and pheromone-controlled proliferation.