I include more information about the molecular mechanisms responsible for “…sex-specific regulation of miRNA levels that are known to influence sexually dimorphism of mRNA concentrations in the brains of mice” and in other species from microbes to man.
The authors are among many, who seem to have missed a likely epigenetic link from maternal and/or acquired ferritin deficiency to thyroxine transport, brain development, and behavior.
“random” mutations in the genome are not quite so random after all.
Across species comparisons of epigenetic effects on genetically predisposed nutrient-dependent and hormone-driven invertebrate and vertebrate social and sexual behavior indicate that human pheromones also alter the development of the brain and behavior via the same molecular mechanisms.
Just as the influence of diet and pheromones can be in the larval stages or in other developmental stages of insects, it can also be in the pre- and postconception stages of mammals, including humans.
Does it make sense to examine the value of a global analysis of gene expression… from any perspective that does not include both the epigenetic effects of nutrient chemicals and the epigenetic effects of pheromones…
There is nothing about the enormous biochemical complexity of the human brain that suggests its complexity could be reduced to a theory in which domain specificity was adaptive in any species from microbe to man.
Most psychologists seem unwilling to admit they don’t know the difference between Pavlovian/classical conditioning and operant/respondent conditioning, perhaps because that would be an admission that they have never treated their clients effectively, which is well known to others whose psychological treatment has failed.
Chemical ecology is, of course, responsible for adaptive evolution via ecological, social, neurogenic, and socio-cognitive niche construction (i.e., brain development). How could anything else but chemicals (nutrient chemicals and pheromones) be responsible for similarities and differences in cell types of the brain in different species?
The epigenetic effects of nutrient chemicals and pheromones during the first 24 months of life are clearly the most important factors involved in the development of the brain and and behavior because….