Wang et al (2013) make it clearer that epigenetic modifications of genes found in social chromosomes entered continuum of adaptive evolution before the sex chromosomes.
“… the “mutational vicinity” is probably found in the molecular vicinity of a “metabolic niche”.
I think what they’ve just shown us exemplifies the molecular biology of epigenetically driven adaptive evolution.
The authors are among many, who seem to have missed a likely epigenetic link from maternal and/or acquired ferritin deficiency to thyroxine transport, brain development, and behavior.
the logic of gene regulatory networks in adaptive evolution does not skip any species.
The only explanation for adaptive evolution with any across species explanatory power is found in my details of the epigenetic effects of olfactory/pheromonal input on intracellular signaling and stochastic gene expression…
Isn’t the diet-responsive and presumably exercise- and pheromone-responsive hypothalamic neurogenic niche most likely to be involved in the cause and effect regulation of HDL via nutrient chemical-dependent epigenetic effects on gonadotropin releasing hormone?