This is an open access article. Any advocate of adaptive evolution via random mutations can attempt to find evidence that I could not find by scanning it.
Changes in food availability, food type, or the way you get food can trigger evolutionary mechanisms to deal with those changes. The result can be increased brain size and cognition, changes in locomotion and even social changes
“random” mutations in the genome are not quite so random after all.
Natural Selection and Sexual Selection must concurrently occur, which makes them non-random processes not driven by random mutations.
the bottom-up epigenetic effects of nutrient chemicals on speciation that are concurrently controlled by the top-down epigenetic effects of pheromones on reproduction challenges those who might rather attempt to-explain away the conserved molecular biology of adaptive evolution via random mutations theory
I mention this only to note the likelihood that random mutations are not driving the disease processes — like Alzheimer’s and that proper nutrition and pheromone therapy offers hope to an aging population.
Does anyone think that what’s reported here exemplifies an effect of a random mutation on ‘junk DNA’?
Stochastic gene expression is not random; it results from nutrient chemicals like glucose entering the cell.