No testable alternative hypothesis

November 25, 2013 | James Kohl

After a few days discussion about epigenetics and my model on the evolutionary psychology Facebook page, I asked about Chromatin, Histones and Modifications: “Do you think that any of this is nutrient-dependent?”  The obvious answer was: “Of course its all nutrient based. I would like to see someone claiming it aint.”

The respondent provided this link to the wikipedia article on metabolism.  Then I asked twice: “Do you think that any of that is not pheromone-controlled?” I’m waiting for an answer from anyone on a Facebook page that gets distributed to more than 7800 members. I’m relatively certain that at least a few other people know chromatin, histones, and modifications are nutrient-dependent. Thus, the pathway that integrates multiple stimuli to produce a coordinated response from yeasts must be the signalling pathway that epigenetically links the nutrient-dependent pheromone-controlled development of the human brain to Mosaic Copy Number Variation in Human Neurons with no need to mention any aspect of mutation-driven evolution. Instead, as the authors of that article note:  “One straightforward hypothesis is that neurons with different genomes will have distinct molecular phenotypes because of altered transcriptional or epigenetic landscapes.”

There is no testable alternative hypothesis involving mutation-initiated natural selection that could even begin to address the experimental evidence that links the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man. That means my model of ecological, social, neurogenic, and socio-cognitive niche construction as it was detailed in The Mind’s Eyes is the model that prevails, whether anyone else ever attests to the obvious fact that all adaptations to the sensory environment in all species are nutrient-dependent and pheromone-controlled. That fact is exemplified by the model organisms I included in my recent review:  Nutrient-dependent/pheromone-controlled adaptive evolution: a model.  It is a model of conserved molecular mechanisms that explain subjective experience.



James Vaughn Kohl

James Vaughn Kohl

James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones.