Business Verified eBay Store Seal Watch Video Watch Video

Unconscious affects on incalculable genomic interactions

Posted on September 16, 2012 by James Kohl.

Job swapping makes its mark on honeybee DNA Switching roles within the hive is reflected in reversible epigenetic  Nicky Guttridge

Excerpt: Gene Robinson… says that although the paper does not necessarily prove that epigenetic mechanisms cause behavioural differences, “it demonstrates for the first time that if behaviour is reversible so is the methylation”.

But Amdam says that the fact that honeybees can revert to a previous role indicates that there is a kind of ‘epigenetic roadmap’. “Brain cells can rely on shifts between these roadmaps to control different behaviours correctly,” she says.

A greater understanding of how epigenetics affects behaviour may lead to insights into human biology, Feinberg says, noting that epigenetic effects on human behaviour might express themselves in addiction, learning and memory. If the link between behaviour and methylation patterns “is true in a bee, it is likely to also be true in us”, he says.


My Comment: Epigenetics can only affect brain-directed behavior by effects on hormones. Moving from the honeybee model organism to vertebrates will be a matter of linking juvenile hormone to luteinizing hormone (LH) secretion that is altered by gonadotropin releasing hormone (GnRH), the biological core of mammalian reproduction. Since the epigenetic effects of nutrient chemicals and pheromones in vertebrates result in changes in intracellular signaling and stochastic gene expression in GnRH neurons; GnRH secretion, and LH secretion, they can be linked to the diversity of genomic interactions that are required in the context of the recently released ENCODE data. However, this is not confabulation!

Gene activation in GnRH neurosecretory neurons of brain tissue in the hypothalamus, for example, links the epigenetic effects of food odors and pheromones to a genetically predisposed and organized GnRH neuronal system and its hormone-driven downstream effects on the development of every other neuronal system linked to differences in behavior via the hypothalamic-pituitary-gonadal and the  hypothalamic-pituitary-adrenal axes as is required for the involvement of both the neuroendocrine and neuroimmune systems in behaviors that ensure species survival.

How else are we going to get from the sensory environment to the diversity of its effects on nutrient chemical-driven behavior and pheromone-controlled mammalian reproduction if not via the diversity of nutrient chemical choices that include heterospecific DNA uptake in microbes, and also include species-specific pheromonal regulation of GnRH via the same molecular mechanisms responsible for nutrient-dependent, pheromone-controlled reproduction and speciation of all organisms?  The reciprocity of the epigenetically altered vertebrate gene, cell, tissue, organ, organ system pathway is clear, as is its role in adaptive evolution via ecological, social, neurogenic, and socio-cognitive niche construction.

As we’ve now seen in invertebrate species, it is olfaction and odor receptors that provide a clear evolutionary trail that can be followed from unicellular organisms to insects to humans. Of course that trail includes transgenerational epigenetic inheritance of nutrient chemical-dependent and pheromone-controlled behaviors, as these authors have indicated. Kudos to them for moving us forward and away from random mutations theory to an era where geneticists and neuroscientists can examine sensory cause and effect in the proper perspective of an epigenetic continuum of unconscious affects on genomic interactions that already include gene duplication as a mechanism of genomic adaptation for behavior that is required in a changing environment of epigenetic effects.

The concept that is extended is the epigenetic tweaking of immense gene networks in ‘superorganisms’ (Lockett, Kucharski, & Maleszka, 2012) that ‘solve problems through the exchange and the selective cancellation and modification of signals (Bear, 2004, p. 330)’. It is now clearer how an environmental drive probably evolved from that of food ingestion in unicellular organisms to that of socialization in insects. It is also clear that, in mammals, food odors and pheromones cause changes in hormones such as LH, which has developmental affects on sexual behavior in nutrient-dependent, reproductively fit individuals across species of vertebrates.

See for review: Kohl, J.V. (2012) Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. Socioaffective Neuroscience & Psychology, 2: 17338. DOI: 10.3402/snp.v2i0.17338.



James Kohl
Retired medical laboratory scientist

James Kohl

Order by Mail or FAX

Order by Mail or Fax

If you prefer to place your pheromones order by MAIL or FAX, using our printable order form, click here.

Trademarks & Notices: LuvEssentials is not affiliated in any way with WebMD, CNN, Discovery Health. All trademarks and registered trademarks appearing on LuvEssentials are the property of their respective owners.

Orders that were shipped by free USPS Mail and are returned to us will be assessed a return processing fee of $7.00 US Dollars. Orders totaling over $190.00 US Dollars, before any discount, that are returned to us will be assessed a return processing fee of 25%.

Please note, the testimonials we display are all real; however, any photos accompanying these testimonials are stock photography, not actual customers. We do this to protect the privacy of our customers.

Also, in accordance with FTC guidelines, we want to make it explicitly clear that the testimonials we display throughout this website are based on the unique experiences that some of our customers have shared with us. We cannot promise that you will experience similar benefits from using our product. If you are not satisfied with our product for any reason, simply return the product within 60 days for a full refund excluding the costs of shipping and handling. Please contact us with any questions you may have.

James Kohl owns, and he has published books and award-winning research journal articles about human pheromones. With colleagues he was the first to show that a mixture of human pheromones increases the flirtatious behaviors of women, and increases their level of attraction to the man wearing the mixture - during a real-life social circumstance lasting 15 minutes.

James Kohl was not paid for his endorsement. Nevertheless, he is an affiliate of which means it is possible for him to receive a monetary gain from the sale of LuvEssentials products based on how the visitor arrived at our site.

For testimonials of LuvEssentials products, please visit our testimonials page here or our ebay reviews page here.

To contact us, please click here

Contact Us

Please complete the following form to contact us; we will reply within one business day.
Business days are Monday through Friday, 9:00 AM to 5:00 PM, EST
The information you are providing here will not be sold or disclosed to any outside party.
(* indicates required fields)

Please contact us by:



Lodix Corporation
138 Palm Coast Parkway N.E.
Suite 192
Palm Coast, FL 32137

What is the vomeronasal organ (VNO)?

The vomeronasal organ (VNO) is a cone-shaped organ in the nasal cavity, which is believed to be one of the body's receptors of pheromones. More, specifically, the VNO, which is part of the accessory olfactory system in the nose, does not respond to normal scents, but may detect odorless, barely perceptible pheromones.

Other schools of thought believe that it is not the VNO but rather cells in our main olfactory system and their affects on hormones secreted by the hypothalamus that are responsible for the affects of pheromones.

Learn more about the science behind pheromones here.

What are optimized pheromones?

Optimized pheromones are lab-certified pheromone formulations that have the optimum concentration of biologically active pheromones scientifically proven to produce behavior-altering results -- particularly as sexual attractants. Optimized pheromone formulations do not necessarily contain the maximum level of pheromones available on the market, but rather contain the greatest degree (and combination)of human pheromones that trigger a conditioned biological response in humans that, in turn, dictate their sexual behavior. Optimized pheromones also release neurotransmitters that directly modify the behavior of the opposite sex, such as triggering sexual excitement. For example:

Optimized pheromones for men are scientifically proven to bring about an increase in the luteinizing hormone (LH) in women, thereby causing a woman to have a heightened sexual responsiveness to a man. This LH surge elevates a woman's predisposition towards sexual activity.

Optimized pheromones for women are scientifically proven to bring about a biochemical surge in men, thereby causing a man to have a heightened sexual responsiveness to a woman. This biochemical surge is what makes a man fiercely determined to copulate.